Treatment of severe salicylate poisoning by forced alkaline diuresis.

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The treatment of salicylate poisoning using mannitol and forced alkaline diuresis.

1. A comparison has been made between alkaline mannitol diuresis and alkaline glucose diuresis in the treatment of salicylate poisoning during an 8 hr period. 2. Mannitol gave a higher rate of urine flow, but there was no significant difference in the rate of salicylate excretion. 3. Serum levels of sodium, potassium and calcium fell in both groups, mainly during the first 2 hr. The mean fall i...

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DUNLOP, D. M. (I963): Eighty-six Cases of Addison's Disease, Brit. med. J., ii, 887. FELix-DAvIEs, D. (1955): Addison's Disease Presenting as Loss of Weight without Pigmentation, Ibid., 48, 1023. FELLOWS, R. E., BUCHANAN, J. R., PETERSON, R. E., STOKES, P. E. (I:962): Chronic Primary Adrenal Insufficiency without Hyperpigmentation, New Engl. Y. Med., 267, 215. JENKINS, D., FORSHAM, P. H., LAIDL...

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Diuresis or urinary alkalinisation for salicylate poisoning?

Forty-four adults with aspirin poisoning were treated with oral fluids only, standard forced alkaline diuresis, forced diuresis alone, or sodium bicarbonate (alkali) alone. Alkali alone was at least as effective and possibly more effective than forced alkaline diuresis in enhancing salicylate removal. Unlike the diuresis regimens it did not cause fluid retention or biochemical disturbances. The...

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The excretion of salicylate in salicylate poisoning.

1. The renal clearance of salicylate has been measured in two groups of patients undergoing treatment by alkaline diuresis for salicylate poisoning. One group received mannitol and sodium lactate, the other acetazolamide and sodium bicarbonate. 2. The relationship between urine pH and salicylate clearance was found to be the same in both groups and similar to that shown at non-toxic concentrati...

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ژورنال

عنوان ژورنال: BMJ

سال: 1969

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.1.5635.35